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KMID : 0545119980080030197
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Journal of Microbiology and Biotechnology
1998 Volume.8 No. 3 p.197 ~ p.202
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Antifungal Activity of Medium-Chain(C_6-C_13) Alkenals against, and Their Inhibitory Effect on the Plasma Membrane H+-ATPase of Saccharomyces cervisiae
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Lee, Jae Ran
Lee, Sang Hwa/Kubo, Isao/Hong, Soon Duck
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Abstract
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Aliphatic alkenals having 6 to 13 carbons were evaluated for antifungal activity against Saccharomyces cerevisiae. The activity was gradually increased with chain length, e.g., (E)-2-decenal and (E)-2-undecenal exhibited maximum potency, while (E)-2-dodecenal and (E)-2-tridecenal were completely inactive. Alkenals showed increasing inhibitory activity with chain length, as in the case of antifungal activity, towards glucose-induced medium acidification by the plasma membrane H^+-ATPase of S. cerevisiae. The group including (E)-2-nonenal, (E)-2-decenal, and (E)-2-undecenal exhibited maximum potency, but the potency of (E)-2-dodecenal and (E)-2-tridecenal demonstrated a sudden drop with respect to the former group. (E)-2-Nonenal revealed dose-reponsive inhibition to the medium acidification and inhibited over 90% at a concentration of 1.25 mM (175.3 ㎍/㎖). In contrast to (E)-2-undecenal whose inhibitory efficiency increased with incubation time, inhibition by (E)-2-dodecenal was reversed with time. Of the tested alkenals, (E)-2-heptenal and (E)-2-octenal most highly inhibited ATP hydrolytic activity by the plasma membrane H^+-ATPase, while (E)-2-heptenal at 10 mM (1121.8 ㎍/㎖) showed an inhibitory efficacy of 93.2%.
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